Bile Duct Cancer
Cholangiocarcinoma (CCA) is a cancerous tumour that forms in the lining of your bile ducts.
The major function of the bile duct is to move a fluid called bile produced in the liver to the gallbladder and small intestine, where it helps digest the fats in food.
Bile ducts within the liver (Intrahepatic ducts) collect the bile via a tributary network of small ductules. The tributaries then form into one common hepatic duct outside the liver.
The common hepatic duct then forms the common bile duct immediately below the junction (branch) that delivers bile to your gallbladder. (For your reference, this branch is known as the cystic duct)
The common bile duct then delivers bile to your Duodenum. (the first stage of the Small intestines)
So now you know the basic anatomy, you are ready to dive a little deeper. Please note that Cholangiocarconoma is often abbreviated as ‘CC’ or ‘CCA’. We will use ‘CCA’
Cholangiocarcinoma starts in the bile duct, a thin tube, about 4 to 5 inches long, that reaches from the liver to the small intestine. The major function of the bile duct is to move a fluid called bile from the liver and gallbladder to the small intestine, where it helps digest the fats in food.
Different parts of the bile duct system have different names. In the liver it begins as many tiny tubes (ductules) where bile collects from the liver cells. The ductules come together to form small ducts, which then merge into larger ducts and eventually the left and right hepatic ducts. The ducts within the liver are called intrahepatic bile ducts. These ducts exit from the liver and join to form the common hepatic duct at the hilum.
About one-third of the way along the length of the bile duct, the gallbladder (a small organ that stores bile) attaches by a small duct called the cystic duct. The combined duct is called the common bile duct. The common bile duct passes through part of the pancreas before it empties into the first part of the small intestine (the duodenum), next to where the pancreatic duct also enters the small intestine.
Cancers can develop in any part of the bile duct and, based on their location, are classified into 3 types:
- Intrahepatic cholangiocarcinoma
- Perihilar cholangiocarcinoma
- Distal cholangiocarcinoma
What is Intrahepatic Cholangiocarcinoma?
Intrahepatic CCA occurs inside the liver where cancer develops in the hepatic bile ducts or the smaller intrahepatic biliary ducts. In some cases, intrahepatic cholangiocarcinoma tumors may have microscopic features of both hepatocellular carcinoma (liver cancer) and cholangiocarcinoma (bile duct cancer) and are considered “combined” or “mixed” tumors.
What is Perihilar (Hilar or Klatskin Tumor) Cholangiocarcinoma?
These cancers develop where the right and left hepatic ducts have joined and are leaving the liver. These are the most common type of cholangiocarcinoma accounting for more than half of all bile duct cancers.
What is Distal Cholangiocarcinoma?
Distal CCA occurs outside the liver after the right and left hepatic bile ducts have joined to form the common bile duct. This type of cancer is found where the common bile duct passes through the pancreas and into the small intestine.
What is Extrahepatic Cholangiocarcinoma?
Because perihilar and distal bile duct cancers start outside the liver, they are often grouped together and referred to as extrahepatic cholangiocarcinoma.
Cholangiocarcinoma can also be divided into types based on how the cancer cells look under the microscope. More than 95% of bile duct cancers are carcinomas and most are adenocarcinomas. Adenocarcinomas are cancers of glandular cells that can develop in several organs of the body. Bile duct adenocarcinomas develop from the mucous glands that line the inside of the duct. Cholangiocarcinoma is another name for a bile duct carcinoma.
Adapted from National Institutes of Health: http://www.nih.gov/